Why the study?
Although recent work clarified the structure of the LPL monomer, the structure of the proposed condensed and inactive LPL oligomer remained opaque.
Population
LPL oligomers and endogenous LPL in vesicles
Design
Cryo-EM reconstruction and superresolution fluorescent microscopy structural study
Authors
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Structural basis for LPL storage may inspire lipid therapies; leaves open translation to human cardiovascular disease.
The study reveals the 3.8-Å structure of a helical LPL oligomer, demonstrating that LPL is condensed into an inactive helical form for intracellular storage.
Gunn et al. (2020) studied this question.
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