Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
January 24, 2003Journal of Internal MedicineOpen Access

HDL from LPL-deficient subjects showed strongly increased PL-acceptance compared with controls (homozygotes 26.46 vs. heterozygotes 3.41 vs. control 1.89 micromol mL-1 h-1/micromol mL-1 PL; all P < 0.05), and CE transfer was highest in homozygotes (72.5%) and lowest in controls (28.7%, P < 0.01).

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Are phospholipid and cholesteryl ester transfer altered in subjects with lipoprotein lipase deficiency compared to healthy controls?

Population

2 homozygous and 6 heterozygous lipoprotein lipase-deficient subjects, and 10 healthy, normolipidaemic…

Design

Case-control

Authors

SKSusanne KaserASA. SandhoferBHB. Hölzl

Discussion

Loading...

Member takes

Overview

Altered HDL transfers may explain low HDL-C in LPL deficiency; hypothesis-generating for atherogenic mechanisms.

Structured PICO

Are phospholipid and cholesteryl ester transfer altered in subjects with lipoprotein lipase deficiency compared to healthy controls?

P
Population
2 homozygous and 6 heterozygous lipoprotein lipase (LPL)-deficient subjects, and 10 healthy, normolipidaemic controls (n=18)
C
Comparator
10 healthy, normolipidaemic controls
O
Outcome
Phospholipid acceptor and donor properties of lipoproteins, PLTP activity, CETP mass, activity and cholesteryl ester (CE) transfersurrogate

Phospholipid and cholesteryl ester transfer are increased in lipoprotein lipase deficiency, which may partly explain the low HDL-cholesterol levels observed in these patients and contribute to atherogenesis.

Cite This Study

Kaser et al. (2003) studied this question.

synapsesocial.com/papers/6a82c2e4c40fc255ce134121https://doi.org/10.1046/j.1365-2796.2003.01091.x
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Reduced cholesteryl ester transfer in plasma of patients with lipoprotein lipase deficiency.1996 · 8 citations
  2. 2Distribution of human plasma PLTP mass and activity in hypo- and hyperalphalipoproteinemia2002 · 31 citations
  3. 3Lipoprotein lipase enhances the cholesteryl ester transfer protein-mediated transfer of cholesteryl esters from high density lipoproteins to very low density lipoproteins.1984 · 94 citations
  4. 4HDL metabolic activities in a boy with lipoprotein lipase deficiency and his family2004 · 4 citations
  5. 5Phospholipid transfer protein gene knock-out mice have low high density lipoprotein levels, due to hypercatabolism, and accumulate apoA-IV-rich lamellar lipoproteins2000 · 110 citations