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August 1, 1984Journal of Biological ChemistryOpen Access

When CETP and LPL were both present, the transfer of cholesteryl esters from HDL into VLDL remnants was enhanced 2- to 8-fold compared to the effects of CETP alone.

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Why the study?

Does the combination of LPL and CETP enhance the transfer of cholesteryl esters from HDL to VLDL compared to CETP alone?

Population

Human or rat VLDL incubated with human HDL

Comparison

Cholesteryl ester transfer protein plus bovine… vs CETP alone or LPL alone

Design

Preclinical

Authors

ATAlan R. TallDSDavid SammettGVG M Vita

Discussion

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Overview

Hypothesis-generating for LPL-CETP synergy in lipoprotein remodeling; human studies required before any clinical relevance.

Structured PICO

Does the combination of LPL and CETP enhance the transfer of cholesteryl esters from HDL to VLDL compared to CETP alone?

P
Population
Human or rat VLDL incubated with human HDL
I
Intervention
Cholesteryl ester transfer protein (CETP) plus bovine milk lipoprotein lipase (LPL)
C
Comparator
CETP alone or LPL alone
O
Outcome
Transfer of cholesteryl esters from HDL to VLDLsurrogate

Lipoprotein lipase synergistically enhances CETP-mediated transfer of cholesteryl esters from HDL to VLDL, a process dependent on active triglyceride hydrolysis.

Cite This Study

Tall et al. (1984) studied this question.

synapsesocial.com/papers/6a83e8b62b578ef1603e985chttps://doi.org/10.1016/s0021-9258(17)42741-4
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Reduced cholesteryl ester transfer in plasma of patients with lipoprotein lipase deficiency.1996 · 8 citations
  2. 2Phospholipid and cholesteryl ester transfer are increased in lipoprotein lipase deficiency2003 · 12 citations
  3. 3Mechanisms of enhanced cholesteryl ester transfer from high density lipoproteins to apolipoprotein B-containing lipoproteins during alimentary lipemia.1986 · 195 citations
  4. 4Plasma phospholipid transfer protein enhances transfer and exchange of phospholipids between very low density lipoproteins and high density lipoproteins during lipolysis.1985 · 193 citations
  5. 5Relationship between lipoprotein lipase and high density lipoprotein cholesterol in mice: modulation by cholesteryl ester transfer protein and dietary status1997 · 37 citations