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October 1, 1997Journal of Lipid ResearchOpen Access

Relationship between lipoprotein lipase and high density lipoprotein cholesterol in mice: modulation by cholesteryl ester transfer protein and dietary status

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Population

Mice expressing the simian CETP transgene and littermates not carrying the CETP gene

Comparison

Expression of simian CETP transgene and/or high… vs Absence of CETP gene and/or chow diet

Design

Preclinical

Authors

SCSusanne M. CleeHZH ZhangNBNagat Bissada

Discussion

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Overview

CETP and diet modulate LPL-HDL correlations in mice; leaves open translation to human lipid metabolism.

Structured PICO

P
Population
Mice expressing the simian CETP transgene and littermates not carrying the CETP gene
I
Intervention
Expression of simian CETP transgene and/or high fat, high carbohydrate diet
C
Comparator
Absence of CETP gene and/or chow diet
O
Outcome
Correlation between plasma lipoprotein lipase (LPL) activity and high density lipoprotein (HDL) cholesterol levelssurrogate

Both genetic (CETP expression) and environmental (diet) factors modulate the association between LPL activity and HDL cholesterol in mice, explaining species differences in lipid metabolism.

Cite This Study

Clee et al. (1997) studied this question.

synapsesocial.com/papers/6a82c2e4c40fc255ce134122https://doi.org/10.1016/s0022-2275(20)37138-8
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Alteration of lipid profiles in plasma of transgenic mice expressing human lipoprotein lipase1994 · 61 citations
  2. 2Overexpression of human lipoprotein lipase in transgenic mice. Resistance to diet-induced hypertriglyceridemia and hypercholesterolemia.1993 · 125 citations
  3. 3Lipoprotein lipase enhances the cholesteryl ester transfer protein-mediated transfer of cholesteryl esters from high density lipoproteins to very low density lipoproteins.1984 · 94 citations
  4. 4Phospholipid and cholesteryl ester transfer are increased in lipoprotein lipase deficiency2003 · 12 citations
  5. 5Induced Mutant Mice Expressing Lipoprotein Lipase Exclusively in Muscle Have Subnormal Triglycerides yet Reduced High Density Lipoprotein Cholesterol Levels in Plasma1997 · 82 citations