Why the study?
Does discontinuation of oral contraceptives resolve hypertriglyceridemia in a patient with recurrent acute pancreatitis?
Does discontinuation of oral contraceptives resolve hypertriglyceridemia in a patient with recurrent acute pancreatitis?
Secondary causes of hypertriglyceridemia, such as oral contraceptive use, must be thoroughly assessed before pursuing genetic screening in young women presenting with acute pancreatitis.
Discontinuation of oral contraceptives may normalize triglycerides in recurrent pancreatitis; hypothesis-generating for secondary cause evaluation before genetic testing in young women.
Hypertriglyceridemia is the third most common cause of acute pancreatitis. Among the causes that lead to secondary hypertriglyceridemia, the use of contraceptive agents is the main reason to be assessed in young women. We report a case of a 31-year-old woman who had suffered two acute pancreatitis episodes secondary to hypertriglyceridemia. In the investigation, the previous medical team indicated a genetic screening before ruling out all secondary causes. LPL, apo CII and apo AV genes were negative for mutations. In the first appointment with us, the patient reported the use of a contraceptive agent for about 2 years. She was instructed to discontinue the drug. After one year of follow-up, her serum triglycerides are within the normal range and a copper intrauterine device was the method chosen by the patient for contraception.
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Stumpf et al. (2018) studied this question.
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