April 1, 1993British Journal of PharmacologyOpen Access

Effects of P1060 and aprikalim on whole‐cell currents in rat portal vein; inhibition by glibenclamide and phentolamine

View Full Paper

Ask AI

Bookmark

Population

Smooth muscle cells of the rat portal vein dispersed by enzymatic treatment

Comparison

Potassium channel openers, P1060 and aprikalim vs Control conditions and exposure to antagonists…

Design

Preclinical

Authors

TITim IbbotsonCairn University GEG. EdwardsUniversity of Denver TNThilo NoackVolkswagen Group (Germany)

Discussion

Member takes

Implication

Hypothesis-generating for vascular KATP pharmacology; leaves open translation to human cardiovascular therapies.

Structured PICO

Population

Smooth muscle cells of the rat portal vein dispersed by enzymatic treatment

Intervention

Potassium (K) channel openers, P1060 (0.3-10 microM) and aprikalim (3-30 microM)

Comparator

Control conditions (absence of K-channel openers) and exposure to antagonists glibenclamide (1 microM) and phentolamine (30-100 microM)

Outcome

Whole-cell currents (IKCO and ITO) measured by voltage-clamp techniquesurrogate

P1060 and aprikalim induce potassium currents in rat portal vein smooth muscle cells by opening ATP-sensitive K-channels, an effect that can be inhibited by glibenclamide and phentolamine.

Cite This Study

Ibbotson et al. (1993) studied this question.

synapsesocial.com/papers/6a82c603236bcdbab08d594e https://doi.org/10.1111/j.1476-5381.1993.tb13496.x

View Full Paper

Ask AI

Bookmark

Effects of P1060 and aprikalim on whole‐cell currents in rat portal vein; inhibition by glibenclamide and phentolamine

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Effects of P1060 and aprikalim on whole‐cell currents in rat portal vein; inhibition by glibenclamide and phentolamine

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider