October 1, 1996British Journal of PharmacologyOpen Access

Effects of cytochrome P450 inhibitors on potassium currents and mechanical activity in rat portal vein

View Full Paper

Ask AI

Bookmark

Population

Freshly-isolated single cells derived from rat portal vein and whole veins

Design

Preclinical

Authors

GEGillian EdwardsUniversity of Manchester PZPeter M. ZygmuntMalmö University EHEdward D. HögestättLund University

Discussion

Member takes

Implication

These P450 inhibitors' K-channel effects warrant experimental caution in vascular studies; leaves open translation to human smooth muscle physiology.

Structured PICO

Population

Freshly-isolated single cells derived from rat portal vein and whole veins

Intervention

Cytochrome P450 inhibitors (proadifen 10-30 microM, clotrimazole 30 microM, and 17-octadecynoic acid [17-ODYA] 5-50 microM)

Outcome

Potassium currents (IK(V), IK(A), IK(ATP), BKCa) and mechanical activity (spontaneous contractions)surrogate

Cytochrome P450 inhibitors profoundly affect various K-channel subtypes in rat portal vein, suggesting cytochrome P450-dependent enzymes regulate smooth muscle K-channel activity.

Cite This Study

Edwards et al. (1996) studied this question.

synapsesocial.com/papers/6a82c637aab30c8fb7b2871a https://doi.org/10.1111/j.1476-5381.1996.tb15728.x

View Full Paper

Ask AI

Bookmark

Implication

These P450 inhibitors' K-channel effects warrant experimental caution in vascular studies; leaves open translation to human smooth muscle physiology.

Effects of cytochrome P450 inhibitors on potassium currents and mechanical activity in rat portal vein

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Effects of cytochrome P450 inhibitors on potassium currents and mechanical activity in rat portal vein

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider