Population
Hairpin ribozyme in the satellite RNA of Tobacco Ringspot Virus
Comparison
Four-way helical junction modification vs Minimal hairpin ribozyme variants
Design
Preclinical
Authors
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May guide ribozyme engineering toward ligation; leaves open in vivo and therapeutic translation.
Tertiary structure stability provided by a four-way helical junction is a major determinant of the hairpin ribozyme's proficiency as a ligase.
Martha J. Fedor (1999) studied this question.
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