Key result
Each one-metabolic equivalent increase in cardiorespiratory fitness was associated with a lower risk of all-cause mortality (RR 0.88; 95% CI 0.83-0.93), as well as CVD and cancer mortality.
Why the study?
Current evidence regarding the associations between cardiorespiratory fitness and mortality was limited, prompting a dose-response meta-analysis in a healthy population.
Does higher cardiorespiratory fitness reduce mortality from all causes, cardiovascular disease, and cancer in a healthy population?
Population
Healthy population across 34 cohort studies
Comparison
Higher vs lowest cardiorespiratory fitness levels or per incremental increase
Design
Dose-response meta-analysis of cohort studies
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Supports fitness promotion in clinical practice; reinforces dose-dependent mortality benefits in healthy adults.
Meta-Analysis
Does higher cardiorespiratory fitness reduce mortality from all causes, cardiovascular disease, and cancer in a healthy population?
Relative Risk: 0.88 (95% CI 0.83–0.93)
Higher cardiorespiratory fitness is associated with a dose-dependent reduction in all-cause, cardiovascular, and cancer mortality in healthy populations.
A 2022 study conducted a meta-analysis in Healthy population. Cardiorespiratory fitness (CRF) vs. Lower CRF was evaluated on All-cause mortality per one-metabolic equivalent increase in CRF (RR 0.88, 95% CI 0.83 to 0.93). Each one-metabolic equivalent increase in cardiorespiratory fitness was associated with a lower risk of all-cause mortality (RR 0.88; 95% CI 0.83-0.93), as well as CVD and cancer mortality.
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