Why the study?
Does olmesartan, bunazosin, or hydralazine reduce left ventricular hypertrophy in a rat model of hyperinsulinemia and insulin resistance?
Population
Male Sprague-Dawley rats fed a high-fructose diet or control diet
Comparison
Olmesartan, bunazosin, or hydralazine… vs Vehicle
Design
Preclinical
Follow-up
4 weeks
Authors
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AT1 blockade may attenuate LVH independently of BP in this rat model; leaves open translation to human hyperinsulinemic states.
Does olmesartan, bunazosin, or hydralazine reduce left ventricular hypertrophy in a rat model of hyperinsulinemia and insulin resistance?
In a rat model of hyperinsulinemia, AT1 receptor antagonism attenuated left ventricular hypertrophy independently of blood pressure lowering, suggesting a direct role of the tissue renin-angiotensin system.
Kamide et al. (2002) studied this question.
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