Key result
Asymptomatic patients with grade I left ventricular diastolic dysfunction exhibited significantly depressed heart rate variability and increased QT dispersion compared to healthy controls.
Why the study?
Imbalance in ventricular repolarization parameters increases the risk of severe arrhythmia and sudden cardiac death, but markers to detect patients at risk during early-stage diastolic dysfunction remain limited.
Are ventricular repolarization parameters and heart rate variability altered in asymptomatic patients with grade I left ventricular diastolic dysfunction compared to healthy controls?
Cross-Sectional (n=47)
Yes
Are ventricular repolarization parameters and heart rate variability altered in asymptomatic patients with grade I left ventricular diastolic dysfunction compared to healthy controls?
Asymptomatic patients with grade I left ventricular diastolic dysfunction exhibit increased ventricular repolarization parameters and depressed heart rate variability, indicating autonomic imbalance and potential higher risk for cardiovascular events.
May signal early autonomic imbalance; leaves open prognostic value or need for intervention in asymptomatic grade I diastolic dysfunction.
Imbalance in ventricular repolarization parameters are related to increased risk of severe arrhythmia and sudden cardiac death. There is limited research regarding markers to detect patients at risk in this early stage. We aimed to assess the influence of grade I left ventricular diastolic dysfunction on repolarization parameters in asymptomatic patients. Ambulatory patients with grade I left ventricular diastolic dysfunction were studied and compared with a control group. We assessed the QT dispersion circadian variation, heart rate variability in the time and frequency domains, and dynamics of QT using a 12-lead Holter. In the diastolic dysfunction group, 8 (30%) patients had QT dispersion > 80 ms. One (3.8%) patient presented premature ventricular complex > 10/h. The comparison between the 2 groups showed that the difference between the standard deviation of normal-to-normal intervals and low frequency power in both groups was statistically significant. We therefore conclude that increased parameters of ventricular repolarization and depressed heart rate variability reflect an imbalance in autonomic responses in patients with grade I left ventricular diastolic dysfunction without cardiovascular symptoms, enabling the identification of patients that are at a higher risk for cardiovascular events.
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Blackman et al. (2019) conducted a cross-sectional in Grade I left ventricular diastolic dysfunction (n=47). Grade I left ventricular diastolic dysfunction vs. Healthy subjects was evaluated on Heart rate variability (standard deviation of normal-to-normal intervals and low frequency power). Asymptomatic patients with grade I left ventricular diastolic dysfunction exhibited significantly depressed heart rate variability and increased QT dispersion compared to healthy controls.
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