Key result
Ischemic heart disease was associated with prolonged 24-hour mean QTo (461 ms vs 426 ms, P<0.01) and abnormal rate dependence compared to healthy subjects, worsening with higher NYHA class.
Why the study?
Do repolarization characteristics (QT/RR relationship) differ between patients with ischemic heart disease and healthy subjects, and do they correlate with symptom severity?
Population
41 patients with ischemic heart disease and varying degrees of left-ventricular impairment, and age-matched…
Design
Case-control
Authors
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May signal heightened arrhythmic risk in IHD; hypothesis-generating for QT/RR-based stratification, needing prospective validation.
Observational
Do repolarization characteristics (QT/RR relationship) differ between patients with ischemic heart disease and healthy subjects, and do they correlate with symptom severity?
Absolute Event Rate: 461% vs 426%
p-value: p=<0.01
Patients with ischemic heart disease and heart failure exhibit progressive abnormalities in repolarization characteristics that correlate with symptom severity, suggesting a mechanism for increased sudden death risk.
Lang et al. (2004) conducted an observational in Ischemic heart disease and heart failure. Ischemic heart disease vs. Healthy subjects was evaluated on 24-hour mean QTo (p=<0.01). Ischemic heart disease was associated with prolonged 24-hour mean QTo (461 ms vs 426 ms, P<0.01) and abnormal rate dependence compared to healthy subjects, worsening with higher NYHA class.
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