What question did this study set out to answer?

Characterize the mechanisms underlying cardiac baroreflex resetting and vagal heart rate deficits in hypertension, focusing on the roles of cardiac loading and angiotensin II.

January 1, 1995Clinical and Experimental Hypertension

Cardiac Baroreflex in Hypertension: Role of the Heart and Angiotensin II

View Full Paper

Ask AI

Bookmark

Design

Review

Authors

PKPaul KörnerAgile Therapeutics (United States)

Discussion

Member takes

Implication

May guide adjunctive LVH or volume reduction to restore baroreflex function in hypertension; leaves open prospective outcome trials.

Key Points

Characterize the mechanisms underlying cardiac baroreflex resetting and vagal heart rate deficits in hypertension, focusing on the roles of cardiac loading and angiotensin II.
Characterized baroreceptor-heart rate reflex dynamics using sigmoid logistic function curves.
Developed an input-output model comparing perivascular cuff and pharmacological interventions that place differing mechanical loads on the heart.
Evaluated the relative contributions of arterial baroreceptors and low- and high-threshold cardiopulmonary baroreceptors.
Normal animals derive approximately 70% of cardiac baroreflex drive from arterial baroreceptors and approximately 30% from low-threshold cardiopulmonary baroreceptors.
Hypertension triggers rapid threshold resetting and a deficit in vagal heart rate control that is worsened by high plasma angiotensin II.
Deficits in heart rate range and reflex gain reverse with reductions in left ventricular hypertrophy or central blood volume rather than blood pressure reductions alone.

Cite This Study

Paul Körner (1995) studied this question.

synapsesocial.com/papers/6a82d05b8aa2f088808d67c7 https://doi.org/10.3109/10641969509087082

Topics

Hypertension management

View Full Paper

Ask AI

Bookmark

Cardiac Baroreflex in Hypertension: Role of the Heart and Angiotensin II

Discussion

Member takes

Implication

Key Points

Cite This Study

Topics

Cardiac Baroreflex in Hypertension: Role of the Heart and Angiotensin II

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Topics

Also Consider