January 1, 1988The Japanese Journal of PharmacologyOpen Access

Calcium Antagonistic Effects and the In Vitro Duration of Actions of KW-3049, a New 1,4-Dihydropyridine Derivative, in Isolated Canine Coronary Arteries

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Population

Isolated canine coronary arteries and electrically-driven canine papillary muscles

Comparison

KW-3049 (a 1,4-dihydropyridine derivative) vs Nifedipine, verapamil, diltiazem, and nitrendipine

Design

Preclinical

Authors

AKAkira KarasawaNew York Structural Biology Center KKKazuhiro KuboKobe University Hospital

Discussion

Member takes

Implication

Supports KW-3049 development as long-acting vasculoselective calcium antagonist; animal in vitro data leave clinical translation open.

Structured PICO

Population

Isolated canine coronary arteries and electrically-driven canine papillary muscles

Intervention

KW-3049 (a 1,4-dihydropyridine derivative)

Comparator

Nifedipine, verapamil, diltiazem, and nitrendipine

Outcome

Calcium antagonistic effects including vasorelaxation (IC50), negative inotropic activities, 45Ca-uptake, and duration of action after washoutsurrogate

KW-3049 is a potent, vasculoselective calcium antagonist with a long duration of action in vitro due to slow dissociation from vascular tissue.

Cite This Study

Karasawa et al. (1988) studied this question.

synapsesocial.com/papers/6a82d087abc87fc4bf1e1fa9 https://doi.org/10.1016/s0021-5198(19)43248-4

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Calcium Antagonistic Effects and the In Vitro Duration of Actions of KW-3049, a New 1,4-Dihydropyridine Derivative, in Isolated Canine Coronary Arteries

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Calcium Antagonistic Effects and the In Vitro Duration of Actions of KW-3049, a New 1,4-Dihydropyridine Derivative, in Isolated Canine Coronary Arteries

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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