Untargeted Lipidomic Profiling of Human Plasma Reveals Differences due to Race, Gender and Smoking Status

concentrations in white subjects of an endogenous endocannabinoid receptor agonist and a choline. Several unidentified features, with masses suggestive of phospholipids or sphingomyelins, were present at lower concentrations in smoking subjects. Since all of these lipids are physiologically important and some have been associated with chronic diseases, our results suggest that young American adults may be predisposed to diseases because of differing lipid concentrations associated with race, gender and smoking.