Why the study?
Does CV4151 reduce ventricular arrhythmias induced by coronary artery occlusion in rats?
Population
66 male Sprague-Dawley rats undergoing coronary artery occlusion
Comparison
CV4151 injected intravenously at 10 mg/kg, 30… vs Saline injected intravenously 5 min before…
Design
Preclinical
Follow-up
30 minutes
Authors
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Does not support clinical use; leaves open translation of TXA2 inhibition to human post-ischemic arrhythmias.
Does CV4151 reduce ventricular arrhythmias induced by coronary artery occlusion in rats?
In a rat model of coronary artery occlusion, the TXA2 synthetase inhibitor CV4151 significantly reduced the incidence of lethal ventricular arrhythmias and mortality.
Umetani et al. (1996) studied this question.
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