Key result
A 64-year-old man with metastatic lung cancer developed rare tricuspid valve nonbacterial thrombotic endocarditis and died within 30 days despite anticoagulation therapy.
Why the study?
Nonbacterial thrombotic endocarditis is a diagnosis of exclusion requiring a high degree of clinical suspicion, and direct oral anticoagulants and surgery lack a clear role in its management.
Case Report (n=1)
This case highlights the rare occurrence of tricuspid valve nonbacterial thrombotic endocarditis in a patient with metastatic lung cancer, emphasizing the need for high clinical suspicion after excluding infective endocarditis.
Nonbacterial thrombotic endocarditis (NBTE) is a pathologic state associated with autoimmune diseases and malignancy in which platelet thrombi are deposited on the heart valves in the absence of a bloodstream infection. NBTE is a diagnosis of exclusion that requires a high degree of clinical suspicion after infective endocarditis etiologies have been ruled out. The treatment of NBTE consists of systemic anticoagulation, with direct oral anticoagulants and surgery not having a clear role. The following case reviews a patient's journey to the diagnosis of tricuspid valve nonbacterial thrombotic endocarditis in the setting of recently diagnosed metastatic lung cancer. This case adds to the growing literature on the diagnostic approach to NBTE.
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Cantor et al. (2022) conducted a case report in Tricuspid Valve Nonbacterial Thrombotic Endocarditis (n=1). Enoxaparin was evaluated on Clinical outcome. A 64-year-old man with metastatic lung cancer developed rare tricuspid valve nonbacterial thrombotic endocarditis and died within 30 days despite anticoagulation therapy.
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