Key result
Inflammatory mediators such as IL-1beta upregulate vascular P2Y(2) receptors at the transcriptional and functional levels through protein kinase C and cyclooxygenase pathways.
Population
Vascular smooth muscle cells (VSMCs)
Comparison
Cytokines and lipopolysaccharide vs Unstimulated cells or cells treated with…
Design
Preclinical
Authors
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Does not support P2Y2 targeting in patients; leaves open its role in human vascular disease.
Inflammatory mediators upregulate vascular P2Y(2) receptors at the transcriptional and functional levels via PKC and COX pathways, potentially contributing to the development of vascular disease.
Hou et al. (2000) studied Atherosclerosis. Cytokines (IL-1beta) was evaluated on Upregulation of P2Y(2) receptor mRNA and functional responses. Inflammatory mediators such as IL-1beta upregulate vascular P2Y(2) receptors at the transcriptional and functional levels through protein kinase C and cyclooxygenase pathways.
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