January 1, 1998Journal of Biological ChemistryOpen Access

Activation of P2Y2 Receptors by UTP and ATP Stimulates Mitogen-activated Kinase Activity through a Pathway That Involves Related Adhesion Focal Tyrosine Kinase and Protein Kinase C

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Population

PC12 cells

Comparison

Extracellular ATP and UTP vs Growth factors and other stimuli

Design

Preclinical

Authors

SSStephen P. SoltoffBoston Medical Center HAHava AvrahamBeth Israel Deaconess Medical Center SAShalom AvrahamNortheastern University

Discussion

Member takes

Implication

Does not support clinical practice changes; leaves open in vivo cardiovascular relevance of this P2Y2 pathway.

Structured PICO

Population

PC12 cells

Intervention

Extracellular ATP and UTP

Comparator

Growth factors (epidermal growth factor, nerve growth factor, insulin) and other stimuli (phorbol 12-myristate 13-acetate, ionomycin)

Outcome

Mitogen-activated protein (MAP) kinase pathway activation and tyrosine phosphorylation of multiple proteinssurrogate

Activation of P2Y2 receptors by UTP and ATP in PC12 cells stimulates MAP kinase activity through a pathway involving calcium elevation, RAFTK, and PKC.

Cite This Study

Soltoff et al. (1998) studied this question.

synapsesocial.com/papers/6a82d78d5b7acbbacb8d6b86 https://doi.org/10.1074/jbc.273.5.2653

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Activation of P2Y2 Receptors by UTP and ATP Stimulates Mitogen-activated Kinase Activity through a Pathway That Involves Related Adhesion Focal Tyrosine Kinase and Protein Kinase C

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Activation of P2Y2 Receptors by UTP and ATP Stimulates Mitogen-activated Kinase Activity through a Pathway That Involves Related Adhesion Focal Tyrosine Kinase and Protein Kinase C

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider