DIxoN AND QUASTEL [1923] investigated the potentials of cysteine-cystine and glutathione-oxidised glutathione mixtures. They observed that these two systems presented peculiar difficulties, in that the potentials exerted at noble metal electrodes were drifting and difficult to reproduce. The platinum-calomel cell usually employed for the determination of the reduction potentials of the type quinol-quinone was found to be unsuitable for work on the RSH-RSSR type, but with the use of the gold-calomel cell satisfactory results were obtained. Unlike the potentials of typically reversible systems, both the cysteine and glutathione potentials depended only upon the PH and the logarithm of the concentration of reduced component. The oxidants in both cases did not affect the electrode. The relationship of the variables in the electrode equation was shown to be the following:
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David Ezra Green (1933) studied this question.