Key result
Increasing medical compliance to ACE-inhibitor therapy from 0.3 to near 1.0 reduced the probability of future hospitalization from approximately 11% to 7% and reduced future mortality rates by half in male patients.
Why the study?
Does medical compliance to ACE-inhibitors improve hospitalization and mortality rates in hypertensive patients?
Population
n=20,339 patients born between 1910 and 1960 residing in a local health authority in Italy, treated with…
Comparison
High medical compliance to ACE-inhibitors vs Low medical compliance to ACE-inhibitors
Design
Cohort
Follow-up
6 years (1997 to 2002)
Authors
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Higher ACE-inhibitor adherence was associated with fewer events in hypertensive men yet reduced by co-payments; leaves open effects of adherence interventions.
Observational (n=14,342)
No
Does medical compliance to ACE-inhibitors improve hospitalization and mortality rates in hypertensive patients?
Absolute Event Rate: 7% vs 11%
Higher compliance to ACE-inhibitors improves hospitalization and mortality rates, but compliance is strongly and immediately reduced by drug co-payments.
Atella et al. (2006) conducted an observational in Hypertension (n=14,342). High medical compliance to ACE-inhibitors vs. Low medical compliance (near 0.3) was evaluated on Probability of future hospitalization. Increasing medical compliance to ACE-inhibitor therapy from 0.3 to near 1.0 reduced the probability of future hospitalization from approximately 11% to 7% and reduced future mortality rates by half in male patients.
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