Key result
Initial use of ACE inhibitors (OR 1.9; 95% CI 1.6-2.2) or calcium channel blockers (OR 1.7; 95% CI 1.5-2.1) was associated with significantly better compliance compared to thiazides in the elderly.
Why the study?
Does the initial choice of antihypertensive drug (ACE inhibitors or calcium channel blockers vs thiazides) improve medication compliance in elderly outpatients?
Population
8,643 outpatients aged 65 to 99 with newly prescribed antihypertensive therapy from 1982 to 1988 in the New…
Comparison
Initial prescription of newer antihypertensive… vs Initial prescription of thiazides
Design
Cohort
Follow-up
12 months
Authors
Loading...
May inform initial antihypertensive selection for adherence in elderly; leaves open causality and needs prospective trials.
Cohort (n=8,643)
Does the initial choice of antihypertensive drug (ACE inhibitors or calcium channel blockers vs thiazides) improve medication compliance in elderly outpatients?
Effect estimate: OR 1.9 (95% CI 1.6 to 2.2)
In elderly patients initiating antihypertensive therapy, the prescription of ACE inhibitors or calcium channel blockers is associated with better medication compliance compared to thiazides.
Mark Monane (1997) conducted a cohort in Hypertension (n=8,643). Angiotensin converting enzyme inhibitors or calcium channel blockers vs. Thiazides was evaluated on Good compliance (≥80%) (OR 1.9, 95% CI 1.6 to 2.2). Initial use of ACE inhibitors (OR 1.9; 95% CI 1.6-2.2) or calcium channel blockers (OR 1.7; 95% CI 1.5-2.1) was associated with significantly better compliance compared to thiazides in the elderly.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: