Key result
The 30-day in-hospital case-fatality rate for acute myocardial infarction declined significantly from 17.0% in 1980-1984 to 7.3% in 1995-1999, representing a 57% reduction.
Why the study?
Does primary PTCA and modern AMI management reduce the 30-day in-hospital case-fatality rate in patients with acute myocardial infarction?
Population
12,961 patients with acute myocardial infarction from a prospective, multicenter, observational registry in…
Comparison
Primary percutaneous transluminal coronary… vs Patients not receiving primary PTCA, and…
Design
Cohort
Follow-up
30 days (in-hospital)
Authors
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Declining AMI fatality supports contemporary management gains; extends observational trends but leaves causal roles of PTCA open.
Observational (n=12,961)
Yes
Does primary PTCA and modern AMI management reduce the 30-day in-hospital case-fatality rate in patients with acute myocardial infarction?
Effect estimate: 57% reduction
Absolute Event Rate: 7.3% vs 17%
p-value: p=<0.001
The in-hospital case-fatality rate for acute myocardial infarction declined by 57% over two decades in Japan, largely driven by reductions in rhythm failure and the adoption of primary PTCA, though pump failure remains a major cause of death.
Watanabe et al. (2001) conducted an observational in Acute myocardial infarction (n=12,961). Later time period (1995-1999) vs. Early time period (1980-1984) was evaluated on 30-day in-hospital case-fatality rate (57% reduction, p=<0.001). The 30-day in-hospital case-fatality rate for acute myocardial infarction declined significantly from 17.0% in 1980-1984 to 7.3% in 1995-1999, representing a 57% reduction.
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