January 1, 2000The Journal of Urology
Effect of Soluble and Insoluble Fiber Diets on Serum Prostate Specific Antigen in Men
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Implication
Randomized crossover trial reveals soluble fiber lowers serum prostate specific antigen in hyperlipidemic men, suggesting an effect linked to enhanced fecal steroid excretion.
Key Points
- Assess whether diets high in soluble versus insoluble dietary fiber alter serum prostate specific antigen levels through changes in sex hormones or fecal steroid excretion.
- Randomized crossover controlled trial in 14 healthy men with hyperlipidemia.
- Participants consumed two 4-month metabolic diets emphasizing soluble or insoluble fiber at approximately 25 to 30 g fiber per 1,000 kcal.
- Evaluated serum prostate specific antigen, free testosterone, estradiol, fecal bile acid, and neutral sterol excretion.
- Mean serum prostate specific antigen was significantly lower with the soluble fiber diet than the insoluble fiber diet (mean difference: 0.07 ± 0.03 ng/ml, p = 0.035).
- Total fecal bile acid output was significantly greater with the soluble fiber diet (341 ± 56 mg daily) compared to the insoluble fiber diet (203 ± 35 mg daily, p = 0.001), and lithocholic acid differences correlated with serum prostate specific antigen changes (r = 0.57, p = 0.035).
- No overall treatment difference was observed for free testosterone or estradiol, though estradiol decreased on the insoluble fiber diet (9 ± 3 pmol/l, p = 0.004).
Cite This Study
Tariq et al. (2000) studied this question.