Key result
Transcatheter aortic valve replacement led to a reduction in arterial wall stiffness of the common carotid artery, with significant improvements in median radial velocity (P<0.0001).
Why the study?
The study aimed to analyze common carotid artery strain properties in patients with severe aortic valve stenosis undergoing TAVR.
Does transcatheter aortic valve replacement (TAVR) improve common carotid artery strain properties and reduce arterial wall stiffness in patients with severe aortic valve stenosis?
Observational (n=59)
Does transcatheter aortic valve replacement (TAVR) improve common carotid artery strain properties and reduce arterial wall stiffness in patients with severe aortic valve stenosis?
p-value: p=<.0001
TAVR significantly reduces arterial wall stiffness of the common carotid artery, with more pronounced improvements observed in patients with more severe aortic valve stenosis.
Post-TAVR carotid strain gains should not yet guide practice; leaves open effects on clinical outcomes in severe aortic stenosis.
The present study aimed to analyze common carotid artery strain properties in patients (n = 59) with severe aortic valve stenosis who underwent transcatheter aortic valve replacement (TAVR). Arterial compliance of the common carotid artery was assessed by ultrasound speckle-tracking before and after TAVR. For sub-analysis the study cohort was divided according to aortic valve area <.75 cm 2 (n = 30) vs ≥.75 cm 2 (n = 29). Comparison of pre- and post-procedural strain variables showed an improvement in median radial velocity ( P < .0001), radial displacement ( P = .007), circumferential strain ( P = .004), radial strain rate ( P = .023), and circumferential strain rate ( P < .0001), while the increase of radial strain showed a trend ( P = .082). Analysis of aortic valve area revealed an inverse correlation between aortic valve area and the differences (post-procedural—pre-procedural values) for radial strain rate, and circumferential strain. Moreover, sub-analysis revealed that the increase of carotid strain variables before and after TAVR were more pronounced in the sub-group of aortic valve area .75 vs ≥.75 cm 2 . TAVR led to a reduction of arterial wall stiffness of the common carotid artery assessed by ultrasound speckle-tracking. The decrease of arterial wall stiffness after TAVR was more pronounced in more severe aortic valve stenosis.
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Kavsur et al. (2023) conducted an observational in severe aortic valve stenosis (n=59). Transcatheter aortic valve replacement (TAVR) vs. Pre-procedural baseline was evaluated on common carotid artery strain properties (median radial velocity) (p=<.0001). Transcatheter aortic valve replacement led to a reduction in arterial wall stiffness of the common carotid artery, with significant improvements in median radial velocity (P<0.0001).
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