Key result
TAVI linked to a ~71% increase in cerebral blood flow immediately after the procedure.
Why the study?
The study aimed to assess arterial cerebral blood flow variations immediately after TAVI in patients with aortic valve stenosis or surgical bioprosthesis degeneration.
Does TAVI improve arterial cerebral blood flow in patients with aortic valve stenosis?
Observational (n=62)
Does TAVI improve arterial cerebral blood flow in patients with aortic valve stenosis?
Absolute Event Rate: 538.67% vs 315.05%
p-value: p=< 0.00001
Carotid Doppler sonography demonstrates immediate and significant improvement in cerebral hemodynamics following TAVI.
TAVI was associated with immediate cerebral blood flow gains in aortic stenosis; hypothesis-generating for clinical outcomes, needs randomized confirmation.
PURPOSE: The aim of our study was to assess the arterial cerebral blood flow variations in patients with aortic valve stenosis, immediately after the transcatheter aortic valve implantation (TAVI). METHODS: The study population includes 62 consecutive patients who underwent TAVI for aortic valve stenosis (95%) and sugical bioprosthesis degeneration (5%). Carotid Doppler examination was performed recording blood flow, systolic peak velocity, time average mean velocity and mean acceleration time at baseline, after balloon aortic valvuloplasty, and within 10 min after the device release. RESULTS: A significant improvement of blood flow was recorded at the end of the procedure (from 315.05 ± 141.72 to 538.67 ± 277.46 ml/min; P < 0.00001). The systolic peak velocity and the time average mean velocity increased from 52.27 ± 14.29 to 78.89 ± 20.48 cm/s (P < 0.00001) and from 12.24 ± 4.74 to 21.21 ± 9 cm/s (P < 0.00001), respectively. Consensually, the mean acceleration time decreased from 0.22 ± 0.02 to 0.03 ± 0.02 s (P < 0.00001) after the procedure. CONCLUSION: Monitoring of Doppler measurements may be a useful and noninvasive method to assess acutely the improvement of hemodynamic flow after TAVI, specifically for the cerebral district.
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Cammalleri et al. (2018) conducted an observational in Aortic valve stenosis and surgical bioprosthesis degeneration (n=62). Transcatheter aortic valve implantation (TAVI) vs. Baseline (pre-procedure) was evaluated on Arterial cerebral blood flow (ml/min) (p=< 0.00001). Transcatheter aortic valve implantation significantly improved cerebral blood flow from 315.05 to 538.67 ml/min (P < 0.00001) immediately after the procedure.
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