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April 22, 2014Clinical Physiology and Functional Imaging

TAVI with the CoreValve system significantly improved aortic valve area (from 0.64 to 1.67 cm2, P<0.001) and mean gradient (from 51.9 to 8.8 mmHg, P<0.001) immediately post-procedure.

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Why the study?

Does TAVI with the CoreValve system improve acute and short-term echocardiographic hemodynamic parameters in high-risk patients with aortic stenosis?

Population

60 high-risk patients with aortic stenosis (26 males, 34 females; mean age 84.7 ± 5.8)

Design

Cohort

Follow-up

3 months

Key result

TAVI with the CoreValve system significantly improved aortic valve area (from 0.64 to 1.67 cm2, P<0.001) and mean gradient (from 51.9 to 8.8 mmHg, P<0.001) immediately post-procedure.

Authors

CSCristina da SilvaASAnders SahlénRWReidar Winter

Discussion

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Member takes

Overview

Supports acute CoreValve TAVI efficacy in small series; leaves open durability and outcome data.

Study Design

Type

Observational (n=60)

Structured PICO

Does TAVI with the CoreValve system improve acute and short-term echocardiographic hemodynamic parameters in high-risk patients with aortic stenosis?

P
Population
60 high-risk patients with aortic stenosis (mean age 84.7 years, 57% female) undergoing TAVI with the CoreValve system, evaluated at baseline, before discharge, and at 3 months.
E
Exposure
Transcatheter aortic valve implantation (TAVI) with the CoreValve system
O
Outcome
Acute and short-term alterations in hemodynamic conditions using echocardiography before hospital discharge and at 3 months follow-upsurrogate

Main Result

Absolute Event Rate: 1.67% vs 0.64%

p-value: p=<0.001

TAVI with the CoreValve system provides immediate and short-term (3-month) improvements in cardiac hemodynamics, including increased aortic valve area, reduced gradients, and favorable left ventricular reverse remodeling.

Cite This Study

Silva et al. (2014) conducted an observational in aortic stenosis (n=60). Transcatheter aortic valve implantation (TAVI) with CoreValve system vs. Baseline (pre-procedure) was evaluated on aortic valve area (AVA) (p=<0.001). TAVI with the CoreValve system significantly improved aortic valve area (from 0.64 to 1.67 cm2, P<0.001) and mean gradient (from 51.9 to 8.8 mmHg, P<0.001) immediately post-procedure.

synapsesocial.com/papers/6ab5fe3f87846ddbf73cf4f8https://doi.org/10.1111/cpf.12153
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Transcatheter aortic valve implantation: 3-year outcomes of self-expanding CoreValve prosthesis2012 · 284 citations
  2. 2Four-year clinical results of transcatheter self-expanding Medtronic CoreValve implantation in high-risk patients with severe aortic stenosis2016 · 4 citations
  3. 3Influence of corevalve revalving system implantation on mitral valve function2011 · 61 citations
  4. 4Short-term effects of transcatheter aortic valve implantation on neurohormonal activation, quality of life and 6-minute walk test in severe and symptomatic aortic stenosis2009 · 118 citations
  5. 5Acute Haemodynamic Impact of Transcatheter Aortic Valve Implantation in Patients with Severe Aortic Stenosis2022 · 14 citations