Key result
Transcatheter aortic valve implantation significantly reduced mean aortic gradient from 58.6 mm Hg to 11.9 mm Hg (p < 0.001) and improved left ventricular ejection fraction.
Why the study?
Does transcatheter aortic valve implantation improve echocardiographic parameters of left ventricular performance and wall thickness in elderly patients with severe symptomatic aortic stenosis unsuitable for surgical aortic valve replacement?
Population
170 consecutive patients with severe symptomatic aortic stenosis unsuitable for surgical aortic valve…
Design
Cohort
Authors
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Supports TAVI-associated LV gains in high-risk severe AS; hypothesis-generating, needs RCTs before practice change.
Observational (n=170)
No
Does transcatheter aortic valve implantation improve echocardiographic parameters of left ventricular performance and wall thickness in elderly patients with severe symptomatic aortic stenosis unsuitable for surgical aortic valve replacement?
Absolute Event Rate: 11.9% vs 58.6%
p-value: p=<0.001
TAVI provides immediate and sustained improvements in left ventricular ejection fraction and wall thickness in high-risk patients with severe aortic stenosis.
Stokłosa et al. (2015) conducted an observational in Severe symptomatic aortic stenosis (n=170). Transcatheter aortic valve implantation (TAVI) vs. Baseline (pre-TAVI) was evaluated on Mean aortic gradient (p=<0.001). Transcatheter aortic valve implantation significantly reduced mean aortic gradient from 58.6 mm Hg to 11.9 mm Hg (p < 0.001) and improved left ventricular ejection fraction.
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