Why the study?
The review aimed to update knowledge regarding sudden unexpected death in epilepsy patient (SUDEP) risks, risk factors, and investigations of putative biomarkers based on suspected mechanisms of SUDEP.
Design
Review
Key result
The overall incidence of sudden unexpected death in epilepsy is 1.2/1000 patient-years, with generalized tonic-clonic seizures as a key risk factor, while reliable predictive biomarkers remain elusive.
Authors
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Supports GTCS frequency monitoring for SUDEP risk stratification; leaves open reliable biomarker development.
This review highlights that while clinical risk factors like generalized tonic-clonic seizure frequency are well established for SUDEP, reliable predictive biomarkers remain elusive.
Ryvlin et al. (2019) conducted a review in Sudden unexpected death in epilepsy (SUDEP). Risk factors and biomarkers was evaluated on Incidence of SUDEP. The overall incidence of sudden unexpected death in epilepsy is 1.2/1000 patient-years, with generalized tonic-clonic seizures as a key risk factor, while reliable predictive biomarkers remain elusive.
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