Population
Chinese hamster ovary cell mutants bearing nonsense codons in four of the five exons of the adenine…
Comparison
Nonsense mutations in the aprt gene; inhibition… vs Wild-type aprt mRNA
Design
Preclinical
Authors
Loading...
No immediate clinical implications for genetic disorders; leaves open applicability of nonsense-mediated decay to cardiovascular transcript regulation.
Nonsense mutations in the aprt gene lead to decreased steady-state mRNA levels through nonsense-mediated destabilization, suggesting translation facilitates mRNA export through nuclear pores.
Kessler et al. (1996) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: