Increased intraluminal pressure (stretch) modulates impulse frequency and conduction in isolated frog sinoauricular chambers, demonstrating a biphasic response.
Stretch modulates firing biphasically in isolated amphibian pacemaker tissue; leaves open relevance to mammalian sinoatrial node mechanosensitivity.
The influence of stretch due to increased intraluminal pressure on the formation and conduction of electrical impulse was studied electrocardiographically in 12 isolated sinoauricular chambers of frog hearts perfused with frogs' Ringer. The impulse frequency was found to be directly proportional to the degree of intraluminal perfusion pressure up to a certain critical head of pressure (2–6 cm Ringer), beyond which the impulse frequency declined. At higher pressures the electrogram showed a diminished amplitude of the action potential and broadening and notching of sinus waves and auricular complexes. The duration and conduction velocity of electrical impulse was increased.
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Chintamani Pathak (1957) studied this question.
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