Key result
Mechanical activation of frog ventricular tissue is similar to electrical activation, with the mechanical activation threshold decreasing as the speed of the applied stretch or baseline stretch increases.
Why the study?
How do different parameters of mechanical stretch affect the activation threshold in frog ventricular tissue?
Population
Geometrically simple sheets of frog (Rana catesbeiana) ventricular tissue (n=25 hearts)
Comparison
Mechanical stretch pulses with varying parameters vs Different parameters of stretch
Design
Preclinical
Authors
Loading...
Caution against clinical extrapolation from frog data; extends electrical activation models but leaves stretch-induced arrhythmogenesis open in mammals.
How do different parameters of mechanical stretch affect the activation threshold in frog ventricular tissue?
Mechanical activation in frog ventricular tissue behaves similarly to electrical activation, with the threshold decreasing at higher stretch speeds and baseline stretch levels.
Fasciano et al. (1999) studied Stretch-induced arrhythmias (n=25). Mechanical stretch pulses vs. Different stretch parameters was evaluated on Mechanical activation threshold. Mechanical activation of frog ventricular tissue is similar to electrical activation, with the mechanical activation threshold decreasing as the speed of the applied stretch or baseline stretch increases.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: