Why the study?
Does mechanical stretch affect the excitation threshold in single frog ventricular myocytes?
Population
Enzymatically dissociated single frog ventricular myocytes
Comparison
Mechanical stretch vs Original resting length (baseline)
Design
Preclinical
Authors
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Does not support clinical changes in pacing thresholds; leaves open whether stretch modulates excitability in mammalian or human myocardium.
Does mechanical stretch affect the excitation threshold in single frog ventricular myocytes?
Mechanical stretch decreases the excitation threshold of frog ventricular myocytes, suggesting a role for mechanosensitive ion channels in cardiac electrophysiology.
Tung et al. (1995) studied this question.
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