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September 1, 1969The Journal of PhysiologyOpen Access

The kinetics of mechanical activation in frog muscle

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Population

Muscle fibres of the frog's sartorius muscle

Design

Preclinical

Authors

RAR. H. AdrianGoogle (United States)WCW K ChandlerThomas Jefferson National Accelerator FacilityAHA. L. HodgkinMarine Biological Association of the United Kingdom

Discussion

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Overview

Voltage-dependent critical durations support second-order kinetics in frog skeletal muscle; leaves open relevance to mammalian cardiac excitation-contraction coupling.

Structured PICO

P
Population
Muscle fibres of the frog's sartorius muscle
I
Intervention
Voltage clamp to control membrane potential and tetrodotoxin to eliminate electrical activity
O
Outcome
Kinetics of mechanical activation and mechanical threshold

The study characterizes the kinetics of mechanical activation in frog sartorius muscle fibers, demonstrating that the overall mechanism is likely second order in time.

Cite This Study

Adrian et al. (1969) studied this question.

synapsesocial.com/papers/6a209449bdfec2d08e8a3111https://doi.org/10.1113/jphysiol.1969.sp008909
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Radial spread of contraction in frog muscle fibres1969 · 141 citations
  2. 2The Mode of Transverse Spread of Contraction Initiated by Local Activation in Single Frog Muscle Fibers1967 · 19 citations
  3. 3Linear electrical properties of striated muscle fibres observed with intracellular electrodes1964 · 356 citations
  4. 4The Mode of Transverse Spread of Contraction Initiated by Local Activation in Single Crayfish Muscle Fibers1967 · 19 citations
  5. 5Frog Skeletal Muscle Fibers: Changes in Electrical Properties after Disruption of Transverse Tubular System1967 · 102 citations