Population
pregnant ewes on the fourteenth day of gestation
Comparison
Ingestion of cyclopamine, its glycoside alkaloid… vs Ingestion of other steroidal alkaloids…
Design
Preclinical
Authors
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Guides livestock exposure avoidance; leaves open human teratogenic relevance pending further study.
Identifies specific steroidal alkaloids from Veratrum californicum as the teratogenic agents causing cyclopian malformations in sheep.
Keeler et al. (1968) studied this question.
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