Key result
The T allele of the ADIPOQ G276T polymorphism was a significant and independent risk factor for the onset of stroke (RR 1.879) in patients with essential hypertension.
Why the study?
Does the T allele of the ADIPOQ G276T SNP increase the risk of stroke and cardiovascular disease in Japanese patients with essential hypertension?
Population
353 Japanese outpatients with essential hypertension. Exclusions: atrial fibrillation or malignant diseases.
Comparison
Presence of the T allele of the ADIPOQ G276T… vs Absence of the T allele of the ADIPOQ G276T SNP
Design
Cohort
Follow-up
mean 7.9±0.2 years
Authors
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Does not support routine ADIPOQ genotyping in hypertension; leaves open prospective validation for stroke risk stratification.
Cohort (n=353)
No
Does the T allele of the ADIPOQ G276T SNP increase the risk of stroke and cardiovascular disease in Japanese patients with essential hypertension?
Relative Risk: 1.879 (95% CI 1.006–3.675)
p-value: p=0.0479
The ADIPOQ G276T T allele is an independent genetic risk factor for stroke in hypertensive patients, likely mediated through increased arterial stiffness rather than serum adiponectin levels.
Kawai et al. (2012) conducted a cohort in Essential hypertension (n=353). T allele of ADIPOQ G276T single nucleotide polymorphism vs. Subjects without the T allele (GG genotype) was evaluated on New onset of stroke (RR 1.879, 95% CI 1.006-3.675, p=0.0479). The T allele of the ADIPOQ G276T polymorphism was a significant and independent risk factor for the onset of stroke (RR 1.879) in patients with essential hypertension.
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