Key result
Individuals in the highest quartile of plasma resistin levels had a significantly increased risk of myocardial infarction compared to the lowest quartile (RR 2.09; 95% CI 1.01-4.31; P for trend=0.01).
Why the study?
Do high plasma resistin levels increase the risk of future myocardial infarction and ischemic stroke in middle-aged subjects without prior cardiovascular disease?
Cohort (n=26,490)
Do high plasma resistin levels increase the risk of future myocardial infarction and ischemic stroke in middle-aged subjects without prior cardiovascular disease?
Answers are grounded in this paper and cite their sources.
High baseline plasma resistin levels are independently associated with a twofold increased risk of future myocardial infarction, but not ischemic stroke, in middle-aged individuals without prior cardiovascular disease.
CONTEXT: Resistin is a hormone that has been linked to insulin resistance, inflammatory processes, and coronary heart disease in case-control studies; however, prospective data on the association between plasma resistin levels and future risk of cardiovascular disease are lacking. OBJECTIVE: The objective of the study was to investigate the association between plasma resistin levels and risk of future myocardial infarction (MI) and ischemic stroke (IS) in a large prospective cohort. METHODS: We investigated the association between plasma resistin levels and risk of MI and IS in a case-cohort design among 26,490 middle-aged subjects from the European Investigation into Cancer and Nutrition-Potsdam Study without history of MI or stroke at time of blood draw. Plasma resistin levels were measured in baseline blood samples of 139 individuals who developed MI, 97 who developed IS, and 817 individuals who remained free of cardiovascular events during a mean follow-up of 6 yr. RESULTS: After multivariable adjustment for established cardiovascular risk factors including C-reactive protein, individuals in the highest compared with the lowest quartile of plasma resistin levels had a significantly increased risk of MI (relative risk 2.09; 95% confidence interval 1.01-4.31; P for trend = 0.01). In contrast, plasma resistin levels were not significantly associated with risk of IS (relative risk 0.94; 95% confidence interval 0.51-1.73; P for trend = 0.88). CONCLUSION: Our data suggest that high plasma resistin levels are associated with an increased risk of MI but not with risk of IS. Further studies are needed to evaluate the predictive value of plasma resistin levels for cardiovascular disease.
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Weikert et al. (2008) conducted a cohort in Myocardial Infarction and Ischemic Stroke (n=26,490). High plasma resistin levels vs. Lowest quartile of plasma resistin levels was evaluated on Myocardial infarction (MI) (RR 2.09, 95% CI 1.01-4.31, p=0.01 for trend). Individuals in the highest quartile of plasma resistin levels had a significantly increased risk of myocardial infarction compared to the lowest quartile (RR 2.09; 95% CI 1.01-4.31; P for trend=0.01).
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