Key result
The fourth quartile of resistin plasma levels was independently associated with an increased risk of noncardiovascular mortality compared to the first quartile.
Why the study?
Are resistin plasma levels associated with angiographic CAD, cardiovascular risk factors, and mortality in subjects undergoing coronary angiography?
Cohort (n=1,162)
Are resistin plasma levels associated with angiographic CAD, cardiovascular risk factors, and mortality in subjects undergoing coronary angiography?
Resistin plasma levels correlate with inflammatory markers and renal function but do not serve as an independent cardiovascular risk factor, though they are unexpectedly associated with noncardiovascular mortality.
Answers are grounded in this paper and cite their sources.
Resistin not independently tied to CAD or CV mortality; leaves open its unexpected non-CV mortality link for prospective study.
BACKGROUND: The adipokine resistin, which is thought to serve as a link between obesity and insulin resistance, was recently shown to exert proatherosclerotic features. OBJECTIVE: Our study aimed to explore the involvement of resistin in cardiovascular disease by investigating the associations of resistin with angiographic coronary artery disease (CAD), cardiovascular risk factors and mortality. DESIGN: The Ludwigshafen Risk and Cardiovascular Health (LURIC) study is a prospective study of white subjects who had undergone coronary angiography. PATIENTS AND MEASUREMENTS: Resistin levels were determined in 1162 subjects with (n = 911) and without (n = 251) angiographic CAD. During a mean follow-up period of 5.47 years, 198 deaths occurred among our probands. RESULTS: Resistin was positively correlated with C-reactive protein (CRP; r = 0.245, P < 0.001), vascular adhesion molecule-1 (VCAM-1; r = 0.327, P < 0.001) and intercellular adhesion molecule-1 (ICAM-1; r = 0.197, P < 0.001) and was negatively correlated with glomerular filtration rate (GFR; r = -0.438, P < 0.001) and high density lipoprotein (HDL; r = -0.196, P < 0.001). Multiple regression analysis revealed that GFR was the strongest predictive variable for resistin. Angiographic CAD, type 2 diabetes, smoking, hypertension and body mass index (BMI) were not associated with resistin. Compared to the first quartile, we observed an increased risk for cardiovascular and noncardiovascular mortality at the fourth quartile of resistin, but only the association between resistin and noncardiovascular mortality remained significant after multivariable adjustments [hazard ratio (HR) 4.92, 95% confidence interval (CI) 1.66-14.6, P = 0.004]. CONCLUSIONS: Resistin plasma concentrations are related to inflammatory processes and renal function but our study does not support the hypothesis of resistin as an independent cardiovascular risk factor. The unexpected association of resistin with noncardiovascular mortality still warrants further study.
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Pilz et al. (2007) conducted a cohort in subjects undergoing coronary angiography (n=1,162). Resistin plasma levels vs. First quartile of resistin was evaluated on noncardiovascular mortality (HR 4.92, 95% CI 1.66-14.6, p=0.004). The fourth quartile of resistin plasma levels was independently associated with an increased risk of noncardiovascular mortality compared to the first quartile.
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