Key result
Plasma resistin levels were significantly elevated in CAD patients with overt heart failure (17.0 ng/ml) compared to those without left-ventricular dysfunction (10.7 ng/ml), an increase primarily driven by reduced kidney function (p < 0.001).
Cross-Sectional (n=107)
No
In patients with CAD and heart failure, elevated plasma resistin levels are primarily mediated by reduced kidney function (eGFR) rather than the severity of left ventricular systolic dysfunction.
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Should not guide management in CAD-HF; leaves open whether resistin adds prognostic value beyond eGFR.
OBJECTIVES: The aim of this study was to evaluate resistin levels in patients with coronary artery disease (CAD) with or without chronic heart failure, in order to define its independent predictor. METHODS: One hundred and seven outpatients with CAD were enrolled in the study and divided into three groups: CAD without left-ventricular systolic dysfunction (group 1); CAD with left-ventricular dysfunction without heart failure symptoms (group 2); CAD with overt heart failure (group 3). Plasma resistin was determined by ELISA. RESULTS: Resistin progressively increased from group 1 (10.7±5.0 ng/ml) to groups 2 (11.8±5.8 ng/ml) and 3 (17.0±6.8 ng/ml), with the difference reaching statistical significance in group 3 versus groups 1 and 2 (P=0.001). A multivariable model of analysis demonstrated that the best predictor of plasma resistin level was the estimated glomerular filtration rate (P<0.001), indicating that reduction of kidney function was the main cause of the adipokine increase observed in patients with CAD and overt heart failure. CONCLUSIONS: Our data confirm the rise of resistin plasma levels previously described in patients affected by chronic heart failure; however, in our study, this relationship seemed to be mediated mainly by the level of kidney function, and only partially by the severity of ventricular dysfunction.
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Baldasseroni et al. (2012) conducted a cross-sectional in Coronary artery disease with or without chronic heart failure (n=107). Overt heart failure vs. CAD without left-ventricular systolic dysfunction was evaluated on Plasma resistin level (ng/ml) (p=0.001). Plasma resistin levels were significantly elevated in CAD patients with overt heart failure (17.0 ng/ml) compared to those without left-ventricular dysfunction (10.7 ng/ml), an increase primarily driven by reduced kidney function (p < 0.001).
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