Why the study?
Do equimolar concentrations of racemic bupivacaine, levobupivacaine, and ropivacaine have different effects on ventricular conduction, refractoriness, and wavelength in isolated rabbit hearts?
Population
Isolated frozen rabbit hearts (which leave a thin layer of surviving epicardial muscle)
Comparison
0.1, 1, and 10 mum racemic bupivacaine… vs Equimolar concentrations of the other agents
Design
Preclinical
Authors
Loading...
These potency ratios in rabbit hearts caution against equimolar assumptions; leaves open human ventricular arrhythmia relevance.
Do equimolar concentrations of racemic bupivacaine, levobupivacaine, and ropivacaine have different effects on ventricular conduction, refractoriness, and wavelength in isolated rabbit hearts?
Differences among racemic bupivacaine, levobupivacaine, and ropivacaine at equimolar concentrations are mainly caused by use-dependent effects on conduction velocities and concentration-dependent effects on ventricular effective refractory period.
Aya et al. (2002) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: