Population
12 isolated perfused hearts from ketamine-anesthetized guinea pigs
Comparison
Perfusion with increasing randomized… vs Comparison between isomer, isomer, and racemate…
Design
Preclinical, randomized concentrations
Authors
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The (+) isomer may heighten AV block risk versus the (-) isomer; hypothesis-generating for safer formulations in humans.
The (+) isomer of bupivacaine exerts a significantly greater delay in AV conduction and higher risk of AV block compared to the (-) isomer in isolated guinea pig hearts.
Gräf et al. (1997) studied this question.
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