Why the study?
Does bupivacaine alter electrophysiologic properties and arrhythmias in an in vitro model of myocardial ischemia and reperfusion?
Population
Guinea pig right ventricular muscle strip in an in vitro model of ischemic and reperfused myocardium
Comparison
Bupivacaine at 1, 5, and 10 microM concentrations vs Simulated ischemia with no drug or control
Design
Preclinical
Authors
Loading...
Alerts to accelerated conduction block risk with bupivacaine in ischemia; hypothesis-generating for concentration-specific arrhythmia effects in reperfusion models.
Does bupivacaine alter electrophysiologic properties and arrhythmias in an in vitro model of myocardial ischemia and reperfusion?
In an in vitro guinea pig model of myocardial ischemia, bupivacaine at higher concentrations induced loss of excitability and reduced reperfusion arrhythmias, while lower concentrations showed proarrhythmic effects during ischemia.
Picard et al. (1998) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: