Why the study?
Does bupivacaine attenuate myocardial tissue acidosis during ventricular fibrillation in a canine model?
Population
16 dogs anesthetized with 1.5% end-tidal isoflurane with open chest
Comparison
Bupivacaine 10 mg/kg administered 3 minutes… vs Sham saline treatment
Design
Preclinical
Authors
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Indicates possible myocardial preservation in VF; leaves open translation to human resuscitation.
Does bupivacaine attenuate myocardial tissue acidosis during ventricular fibrillation in a canine model?
Pretreatment with bupivacaine significantly attenuated the progression of myocardial acidosis during ventricular fibrillation in dogs, indicating potential for myocardial preservation.
Weinberg et al. (2004) studied this question.
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