Why the study?
Does bupivacaine affect myocardial contraction and membrane potential in isolated canine papillary muscles?
Does bupivacaine affect myocardial contraction and membrane potential in isolated canine papillary muscles?
Bupivacaine depresses myocardial contraction in canine papillary muscles, likely via Na+ channel blockade at low concentrations and Ca2+ channel blockade at higher concentrations.
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Observed effects in canine papillary muscle are hypothesis-generating; human translation and clinical implications require further study.
Shibuya et al. (2008) studied this question.
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