Why the study?
Does bupivacaine compared to lidocaine have different electrophysiologic and arrhythmogenic effects in isolated canine hearts?
Does bupivacaine compared to lidocaine have different electrophysiologic and arrhythmogenic effects in isolated canine hearts?
Bupivacaine is significantly more potent than lidocaine in depressing cardiac electrophysiologic function and inducing arrhythmias like sinoatrial block in a canine model.
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Bupivacaine's higher potency in canine hearts warrants dosing caution; leaves open translation to human arrhythmogenic risk.
Wheeler et al. (1988) studied this question.
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