Why the study?
Does bupivacaine differ from lidocaine in myocardial uptake and disposition kinetics in an isolated rabbit heart model?
Population
Isolated rabbit heart model with constant coronary inflow
Comparison
Bupivacaine vs Lidocaine
Design
Preclinical
Authors
Loading...
Greater bupivacaine QRS widening may explain clinical cardiotoxicity differences; leaves open translation from rabbit model to humans.
Does bupivacaine differ from lidocaine in myocardial uptake and disposition kinetics in an isolated rabbit heart model?
The severe cardiac dysrhythmias caused by bupivacaine compared to lidocaine are likely due to pharmacodynamic differences (greater maximum QRS widening) rather than differences in myocardial uptake and disposition kinetics.
Mazoit et al. (1993) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: