What question did this study set out to answer?

To evaluate and compare the cardiac electrophysiologic effects of increasing and decreasing concentrations of bupivacaine and lidocaine on transmembrane action potentials.

February 1, 1988Anesthesia & Analgesia

Cardiac Electrophysiologic Effects of Lidocaine and Bupivacaine

View Full Paper

Ask AI

Bookmark

Why the study?

Do bupivacaine and lidocaine have different electrophysiologic effects on transmembrane action potentials in an isolated rabbit Purkinje fiber-ventricular muscle model?

Population

Isolated rabbit Purkinje fiber-ventricular muscle model

Comparison

Bupivacaine and Lidocaine vs Comparison between bupivacaine and lidocaine…

Design

Preclinical

Authors

RMR. A. MollerHelios Hospital Berlin-Buch BCBenjamín G. CovinoBoston College

Discussion

Member takes

Implication

May heighten LAST reentry risk with bupivacaine; hypothesis-generating for human translation.

Key Points

To evaluate and compare the cardiac electrophysiologic effects of increasing and decreasing concentrations of bupivacaine and lidocaine on transmembrane action potentials.
Measured transmembrane action potentials under progressively increasing and decreasing concentrations of bupivacaine and lidocaine in an isolated rabbit Purkinje fiber-ventricular muscle model.
Bupivacaine (3 and 5 µg/ml) significantly decreased diastolic resting potential, maximum rate of depolarization, and action potential amplitude, showing effects distinct from lidocaine (10–20 µg/ml).
High concentrations of bupivacaine (30 µg/ml) and lidocaine (100 µg/ml) caused delayed conduction and ultimately complete conduction blockade between Purkinje fibers and ventricular muscle cells.
The duration of conduction blockade was significantly longer with bupivacaine than with lidocaine.

Structured PICO

Do bupivacaine and lidocaine have different electrophysiologic effects on transmembrane action potentials in an isolated rabbit Purkinje fiber-ventricular muscle model?

Population

Isolated rabbit Purkinje fiber-ventricular muscle model

Intervention

Bupivacaine (3, 5, and 30 micrograms/ml) and Lidocaine (10-20 and 100 micrograms/ml)

Comparator

Comparison between bupivacaine and lidocaine effects

Outcome

Effects on transmembrane action potentials (diastolic resting potential, maximum rate of depolarization, action potential amplitude, and conduction)surrogate

Bupivacaine induces more severe electrophysiologic derangements and longer conduction blockade than lidocaine in rabbit cardiac tissue, potentially increasing the risk of reentrant ventricular arrhythmias.

Cite This Study

Moller et al. (1988) studied this question.

synapsesocial.com/papers/6a82ddccaab30c8fb7b28969 https://doi.org/10.1213/00000539-198802000-00002

View Full Paper

Ask AI

Bookmark