April 1, 1985AnesthesiologyOpen Access

Mechanism for Bupivacaine Depression of Cardiac Conduction

View Full Paper

Ask AI

Bookmark

Population

Guinea pig ventricular muscle

Comparison

Bupivacaine (>0.2 micrograms/ml) vs Lidocaine (5-10 micrograms/ml)

Design

Preclinical

Authors

CCC W ClarksonTulane University LHLuc M. HondeghemFlanders Marine Institute

Discussion

Member takes

Implication

Supports clinical caution with bupivacaine; leaves open human confirmation of accumulation kinetics.

Structured PICO

Population

Guinea pig ventricular muscle

Intervention

Bupivacaine (>0.2 micrograms/ml)

Comparator

Lidocaine (5-10 micrograms/ml)

Outcome

Maximum upstroke velocity of the action potential (Vmax) and sodium channel block kineticssurrogate

Bupivacaine's slow dissociation from cardiac sodium channels leads to cumulative block at normal heart rates, explaining its severe and refractory cardiotoxicity.

Cite This Study

Clarkson et al. (1985) studied this question.

synapsesocial.com/papers/6a82dd20fb68d755121c272e https://doi.org/10.1097/00000542-198504000-00006

View Full Paper

Ask AI

Bookmark

Mechanism for Bupivacaine Depression of Cardiac Conduction

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Mechanism for Bupivacaine Depression of Cardiac Conduction

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider