Why the study?
Does bupivacaine exacerbate electrophysiological disorders and accelerate ventricular fibrillation during myocardial ischemia in a pig model?
Population
30 anesthetized, open-chest pigs
Comparison
Bupivacaine i.v. combined with transient… vs Bupivacaine i.v. alone or ischemia alone
Design
Preclinical
Follow-up
up to 8 minutes
Authors
Loading...
Bupivacaine hastens VF onset during ischemia in pigs; leaves open human relevance and precludes practice change.
Does bupivacaine exacerbate electrophysiological disorders and accelerate ventricular fibrillation during myocardial ischemia in a pig model?
Bupivacaine significantly shortens the time to ventricular fibrillation during acute myocardial ischemia in a pig model, suggesting caution is needed when using it in patients with ischemic heart disease.
Freysz et al. (1993) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: