Why the study?
Do cardiovascular drugs such as cibenzoline, disopyramide, and propranolol prolong conduction time in a canine model, potentially exacerbating bupivacaine-induced conduction disorders?
Population
30 anesthetized, closed-chest dogs
Design
Preclinical
Authors
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May warrant caution with bupivacaine in this canine model; leaves open translation to human practice.
Do cardiovascular drugs such as cibenzoline, disopyramide, and propranolol prolong conduction time in a canine model, potentially exacerbating bupivacaine-induced conduction disorders?
Cardiovascular drugs such as cibenzoline, disopyramide, and propranolol prolong ventricular conduction time, suggesting caution when using bupivacaine regional anesthesia in patients taking these medications.
Timour et al. (1990) studied this question.
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